Author/Authors :
Farvardin, Mohsen Department of Ophthalmology - Poostchi Ophthalmology Research Center - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Mousavi, Esmaeil Department of Ophthalmology - Poostchi Ophthalmology Research Center - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Zare, Kamran Department of Ophthalmology - Poostchi Ophthalmology Research Center - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Bazdar, Somaye Department of Ophthalmology - Poostchi Ophthalmology Research Center - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Farvardin, Zahra Department of Ophthalmology - Poostchi Ophthalmology Research Center - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Johari, Mohammadkarim Department of Ophthalmology - Poostchi Ophthalmology Research Center - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Purpose: To investigate possible links between thyroid dysfunction and prevalence of wet age‑related macular degeneration (AMD).
Methods: The present case–control study enrolled a total number of 90 patients with wet AMD and 90 sex‑, and age‑matched controls through
a convenient sequential sampling method. Thyroid hormones were profiled in serum assay. Statistical measures were done to compare means
between groups.
Results: Our findings showed a significant difference in free T4 levels between wet AMD and control groups (P = 0.002), but the mean values
of total T3 and Thyroid‑stimulating hormone levels were similar between the two groups. In addition, there were no differences in serum lipid
profile between groups. Although no significant difference in the history of hypertension and hyperlipidemia between wet AMD and control
groups was found, the history of smoking was higher in controls (P = 0.039).
Conclusion: Thyroid hormone abnormalities may be associated with wet AMD.
