Relationship between Adenosine Deaminase with Ectopic Pregnancy in Pregnant Women Referred to Motahari Hospital in Urmia (2017-2018)

Background & Objective: One of the most common causes of maternal mortality in the first trimester of pregnancy is ectopic pregnancy (EP). Adenosine deaminase (ADA) plays an essential role in production, maturation and function of lymphoid cells, which is produced in all tissues of the body. Total serum adenosine deaminase levels decrease during normal pregnancy. Considering the importance of early detection of EP, this study aimed to investigate the relationship between adenosine deaminase and EP in pregnant women referred to Motahari Hospital in Urmia from 2017 to 2018. Materials & Methods: This study consisted of two groups of patients including patients with EP as a case group and patients with normal pregnancy confirmed by sonography as a control group. The level of βHCG and serum ADA levels were compared in the two groups. P-values less than 0.05 were considered as significant. Results: In this study, 94 pregnant women were enrolled, including 47 patients as control group with normal pregnancy and 47 patients as case group with EP. The mean ADA level in patients with EP and the control group were 12.21±8.17 IU/L and 8.44±6.21 IU/L (P=0.01), respectively. The mean βHCG level in women with EP was 3215.60±1400.71 mIU/mL. In women with normal pregnancy, it was 11926.96±3408.23 mIU/mL (P=0.001). Conclusion: High levels of ADA can be helpful in the early diagnosis of EP.