Title of article :
A Remarkable Zirconium(IV) Chloride Catalyzed Highly Selective Deprotection of t-Butyldimethylsilyl (TBS) Ethers in Presence of t-Butyldiphenylsilyl (TPS) Ethers#
Author/Authors :
Sharma, G.V.M. Indian Institute of Chemical Technology - Organic Chemistry Division-III - D-211, Discovery Laboratory, India , Srinivas, B. Indian Institute of Chemical Technology - Organic Chemistry Division-III - D-211, Discovery Laboratory, India , Krishna, Palakodety Radha Indian Institute of Chemical Technology - Organic Chemistry Division-III - D-211, Discovery Laboratory, India
Abstract :
A highly selective and efficient method for the chemoselective deprotection of t-butyldimethylsilyl(TBS) ethers using 20 mol% of zirconium(IV) chloride as Lewis acid in isopropanol is reported. remarkable selectivity was observed towards the TBS group deprotection while TPS remains unaffected. The reaction is fast and the conditions are tolerable to a variety of protecting groups, carbohydrates and terpenes. The products are obtained in excellent yields.
Keywords :
Zirconium(IV) chloride , chemoselective deprotection , isopropanol , t , butyldimethylsilyl ethers , t , butyldiphenylsilyl ethers
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
