Author/Authors :
Brewster, A.G. Alderley Park, Macclesfield - AstraZeneca Pharmaceuticals, Mereside, UK , Broady, S. Alderley Park, Macclesfield - AstraZeneca Pharmaceuticals, Mereside, UK , Glenna, E. The University of Oxford - The Department of Chemistry - Chemical Research Laboratory, UK , Hermitage, S.A. The University of Oxford - The Department of Chemistry - Chemical Research Laboratory, UK , Hughes, M. The University of Oxford - The Department of Chemistry - Chemical Research Laboratory, UK , Moloney, M.G. The University of Oxford - The Department of Chemistry - Chemical Research Laboratory, UK , Woods, G. The University of Oxford - The Department of Chemistry - Chemical Research Laboratory, UK
Abstract :
The cycloadditions of a [4.3.0]-bicyclic alpha,beta-unsaturated lactam, derived from 6-oxopipecolic acid, have been investigated. Although yields are modest, diastereoselectivity is high; reasons for the low reactivity are postulated, based on experimental observations and molecular modelling.
