Title of article :
Influence of Homoallylic Fluorine Atoms on the Regioselectivity of theWacker Reaction
Author/Authors :
Guidotti, J. Université de Versailles - UMR CNRS - SIRCOB, France , Tordeux, M. Université de Versailles - UMR CNRS - SIRCOB, France , Blazejewski, J.-C. Université de Versailles - UMR CNRS - SIRCOB, France , Wakselman, C. Université de Versailles - UMR CNRS - SIRCOB, France
Abstract :
Wacker oxidation reaction of terminal olefins bearing one or two fluorine atoms at a homoallylic position led to a ratio aldehyde/methyl ketone much higher than that observed with their non-fluorinated analogues. This regioselectivity can be ascribed to a specific interaction between fluorine atoms and palladium, or to a peculiar influence of the halogens on the double bond.
Keywords :
Wacker reaction , palladium , fluorine , regioselectivity
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
