Title of article :
Chemistry for DOTA Peptide Labeling at Phenylalanine Residues: On the Road to Preparing Peptide Ligand Tagged Libraries
Author/Authors :
León-Rodrígueza, Luis M. De Universidad de Guanajuato - Instituto de Investigaciones Científicas, México , Kovacs, Zoltan Macrocyclics, USA , Sherry, Alan D. University of Texas at Dallas - Department of Chemistry, USA
Abstract :
Different synthetic strategies to control the position of DOTA in phenylalanine residues within apeptide sequence were studied and compared. The results showed that use of DOTA pre-labeled amino acids stands as the most promising procedure for the synthesis of peptide ligand tagged libraries by solid phase peptide synthesis.
Keywords :
Peptide , DOTA , tag , phenylalanine , MRI
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
