Title of article :
Annulation of a 4-pyrrolylbutanal to a 5,6-dihydroindolizine Core: A Novel Diastereoselective Synthesis of (±)-Indolizidine 167B
Author/Authors :
Settambolo, Roberta Università di Pisa - ICCOM-CNR, Sezione di Pisa - Dipartimento di Chimica e Chimica Industriale, Italy , Guazzelli, Giuditta Università di Pisa - Dipartimento di Chimica e Chimica Industriale, Italy , Lazzaroni, Raffaello Università di Pisa - Dipartimento di Chimica e Chimica Industriale, Italy
Abstract :
The synthesis of (±)-Indolizidine167B has been accomplished in 4 steps and 13.5 % overall yieldfrom 4-carboxyethyl-4-(pyrrol-1-yl)butanal (1) via successive manipulations of 5,6-dihydroindolizineintermediates and final diastereoselective hydrogenation.
Keywords :
4 , Pyrrolylbutanal , intramolecular cyclodehydration , indolizidine 167B , 5 , 6 , dihydroindolizines
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
