Title of article :
Development of Organoiron Methodology for the C8-C16 Dienylamine Segment of the Streptogramin Antibiotics
Author/Authors :
Ahmed, Fahim Marquette University - Department of Chemistry, USA , Cao, Yeyu Marquette University - Department of Chemistry, USA , Donaldson, William A. Marquette University - Department of Chemistry, USA
Abstract :
Methodology for preparation of the C8-C16 dienylamine segment of the streptogramin antibiotics isbased on a diastereoselective nitrile oxide-olefin cycloaddition to a (triene)iron complex. The Fe(CO)3 adjunct also serves as a protecting group for the subsequent reductive hydrolysis of the isoxazoline ring.
Keywords :
Streptogramin antibiotics , (diene)iron complexes , cyclocondensation
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
