Title of article :
Some Observations on the Preparation of Amides and their Reduction to Amines in Ionic Liquids
Author/Authors :
Lampariello, Lucia Raffaella Università degli Studi di Siena - Dipartimento di Chimica, Italy , Peruzzi, Daniela Università degli Studi di Siena - Dipartimento Farmaco Chimico Tecnologico, Italy , Sega, Alessandro Università degli Studi di Siena - Dipartimento Farmaco Chimico Tecnologico, Italy , Taddei, Maurizio Università degli Studi di Siena - Dipartimento Farmaco Chimico Tecnologico, Italy
Abstract :
The preparation of amides in ionic liquids was explored using the Schotten-Baumann procedure, theWeinreb amidation of esters and the classical coupling reaction using EDC, HBTU or DMTMM as the coupling agents. In any case amides were obtained in comparable or better yields and with a simplified procedure than using conventional solvents. Moreover, the amides were directly reduced in the same flask to the corresponding secondary or tertiary amines by heating in the presence of solid sodium borohydride.
Keywords :
Amides , amines , ionic liquids , reduction
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
