Title of article :
A Stereoselective Aldol–Reduction Approach to Polyoxygenated Natural Products. Synthesis of C1–C6 Fragment of Erythronolides
Author/Authors :
Galobardes, Marta Universitat de Barcelona - Departament de Química Orgànica, Spain , Gascón, Miguel Universitat de Barcelona - Departament de Química Orgànica, Spain , Rome, Pedro Universitat de Barcelona - Departament de Química Orgànica, Spain , Urpí, Fèlix Universitat de Barcelona - Departament de Química Orgànica, Spain
Abstract :
A new synthetic approach directed toward the preparation of C1–C6 fragment of erythronolides isdisclosed. The core of the process takes advantage of a highly stereoselective sequence based on a boron–mediated aldol reaction of a lactate–derived chiral ketone followed by a syn-reduction of the resulting adduct.
Keywords :
Aldol reaction , boron enolates , chiral ketones , erythronolides , stereoselective synthesis
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
