Title of article :
A Simple and Effective Method for the Thionation of Amides to Thioamides Using Al2O3-Supported P4S10
Author/Authors :
Poupaerta, Jacques H. Université Catholique de Louvain - School of Pharmacy, Belgium , Carato, Pascal Université de Lille 2 - ICPAL, France , McCurdy, Christopher R. University of Mississippi - School of Pharmacy - Department of Medicinal Chemistry, USA
Abstract :
A simple and effective method for the thionation of amides to thioamides using Al2O3-supportedP4S10 was developed and applied to a series of amides including some heterocyclic examples. The reaction was best performed in anhydrous dioxane at reflux temperature. Yields ranging from 62 – 93% are comparable to, or superior to those obtained with Lawesson’s reagent. The method uses inexpensive reagents and has the advantage that reagent-derived byproducts may be removed by a simple hydrolytic workup rather than by chromatography, as required for Lawesson’s reagent.
Keywords :
Thioamide , thionation , heterocycles , lawesson’s reagent , supported reagents
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
