Title of article :
Synthesis of Azlactones, Phenylpyruvic Acid and 1,2,4-Triazine Derivatives Under Microwave Irradiation
Author/Authors :
El Ashry, El Sayed H. Alexandria University - Faculty of Science - Department of Chemistry, Egypt , Ramadan, El Sayed Alexandria University - Faculty of Science - Department of Chemistry, Egypt , Hamid, Hamida Abdel Alexandria University - Faculty of Science - Department of Chemistry, Egypt , Hag, Mohamed Alexandria University - Faculty of Science - Department of Chemistry, Egypt
Abstract :
Microwave (MW) irradiation has been used in each step for the transformation of acyl glycines 2 to 6-benzyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one (7a), and its 4-phenyl derivatives 7b and 7c. The oxazolone 3a was also transformed to phenylpyruvic acid 5, whose thiosemicarbazone 6 can be cyclized to 7aunder MW. Methylation of 7c gave the respective S- and / or N-methylated derivatives, 8 and 9, based on the reaction conditions
Keywords :
Microwave , azlactones , 1 , 2 , 4 , triazine , thiosemicarbazone , phenylpyruvic acid
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
