Title of article :
A Facile Synthesis of Chiral Isocyanate-phenol and Unsymmetrical Urea Derived from Tyrosines without Protecting Phenolic Hydroxyl Groups
Author/Authors :
Nagai, Atsushi Yamagata University - Faculty of Engineering - Department of Polymer Science and Engineering, Japan , Ochiai, Bungo Yamagata University - Faculty of Engineering - Department of Polymer Science and Engineering, Japan , Endo, Takeshi Yamagata University - Faculty of Engineering - Department of Polymer Science and Engineering, Japan
Abstract :
A facile method for synthesis and isolation of chiral isocyanate-phenols, obtained from the reactions of L-tyrosine and L-DOPA [L-3-(3,4-dihydroxyphenyl)alanine] derivatives with di-tert-butyltricarbonate(DBTC), is described. Reaction of the obtained isocyanate-phenol with n-butylamine gave the correspondingchiral unsymmetrical urea
Keywords :
Isocyanate , phenol , unsymmetrical , urea , tyrosine , DOPA , di , tert , butyltricarbonate
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
