Title of article :
Synthesis of alpha-Amino-omega-Hydroxy-Polyethylene Glycol OligodeoxyribonucleotideConjugates
Author/Authors :
Chernov, Boris K. Argonne National Laboratory - Biodetection Technologies Section, USA , Chandler, Darrell P. Argonne National Laboratory - Biodetection Technologies Section, USA , Golova, Julia B. Argonne National Laboratory - Biodetection Technologies Section, USA
Abstract :
Synthesis of N-9-(fluorenylmethyloxycarbonyl)-a-aminopolyethylene glycol 900-ω-(2-cyanoethyl)-N-diisopropyl phosphoramidite is reported. Aminopolyethylene glycol 900-oligodeoxyribonucleotide conjugates were synthesized by solid phase approach by using the newly described phosphoramidite. The reactivity of the amino function in synthetic conjugates was demonstrated by reaction with activated esters of methacrylic acid, Fmoc-L-alanine and Lissamine Rhodamine sulfonyl chloride.
Keywords :
Synthetic methods , Poly(ethylene) glycol , Phosphoramidites , Oligonucleotides , Conjugates
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
