Author/Authors :
Hosoi, Shinzo Kyushu University of Health and Welfare - School of Pharmaceutical Sciences, Japan , Serata, Jun Kanazawa University - Faculty of Pharmaceutical Sciences, Japan , Sakushima, Akiyo Kyushu University of Health and Welfare - School of Pharmaceutical Sciences, Japan , Kiuchi, Fumiyuki National Institute of Biomedical Innovation - Reserch Center for Medicinal Plant Resources, Japan , Takahashi, Ichiro Fukui University - Faculty of Engineering - Department of Applied Chemistry and Biotechnology, Japan , Ohta, Tomihisa Kanazawa University - Faculty of Pharmaceutical Sciences, Japan
Abstract :
Induced circular dichroism (ICD) was observed in binaphthyl amides of chiral primary amines. The CDs changed to split curves centered at 225 nm after N-methylation. The calculated screw senses of the two naphthyl groups accorded with those expected from their exciton chiralities, indicating a possible application for determination of absolute configuration.
Keywords :
Induced circular dichroism , binaphthyl , amide , Cotton effect , exciton chirality , screw sense.
