Title of article :
Design and Synthesis of Spirocyclics Via the Diels Alder Reaction and Ring-Opening Cross-Metathesis as Key Steps
Author/Authors :
Kotha, Sambasivarao Indian Institute of Technology - Department of Chemistry, India , Deb, Ashoke Chandra Bhabha Atomic Research Centre - Bioorganic Division, India , Chattopadhyayb, Subrata Bhabha Atomic Research Centre - Bioorganic Division, India
Abstract :
Ring-opening-cross-metathesis (ROCM) reaction has been used to prepare spiro-indane derivatives containing six rings. The Diels-Alder (DA) chemistry of indan-2-spiro(cyclopenta-2,4-diene) 1 with various dienophiles such as 1,4-benzoquinone and its derivatives gave the corresponding DA products in moderate togood yields. Also, we report an improved procedure for preparation of the spiro-diene 1 using phase-transfercatalysis (PTC) conditions.
Keywords :
Spirocycles , ROCM , Diels , Alder , Grubbs Catalyst , Quinones , Spiro , diene , Fenestranes
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
