Author/Authors :
Han, Zhi-jian Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Daa, Chao-shan Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Qiu, Li Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Ni, Ming Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Zhou, Yi-feng Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China , Wang, Rui Chinese Academy of Sciences - Lanzhou Institute of Chemical Physics - State Key Laboratory for Oxo Synthesis and Selective Oxidation, China , Wang, Rui Lanzhou University - School of Life Sciences - Department of Biochemistry Molecular Biology, China
Abstract :
Several simple amino acids derived chiral sulfonamide ligands were synthesized in simple three steps. When we used these ligands in the asymmetric addition of phenylacetylene to aldehydes, the corresponding propargylic alcohols were isolated with good yields. The highest ee value was obtained up to 99%. The results proved that the backbone of the chiral source greatly influenced the enantioselectivity.
Keywords :
Sulfonamide alcohol, asymmetric addition , phenylacetylene, aldehyde
