Title of article :
Cyanosilylation of Hetero-Substituted Ketones Catalyzed by LiCl
Author/Authors :
Kurono, Nobuhito Hokkaido University - Graduate School of Engineering - Division of Chemical Process Engineering, Japan , Suzuki, Ken Hokkaido University - Graduate School of Engineering - Division of Chemical Process Engineering, Japan , Ohkuma, Takeshi Hokkaido University - Graduate School of Engineering - Division of Chemical Process Engineering, Japan
Abstract :
LiCl efficiently catalyzes cyanosilylation of various hetero-substituted ketones. α,α-Dialkoxyketones are completely converted to silylated cyanohydrins with a substrate-to-catalyst molar ratio of 100,000 at room temperature. Acetophenones substituted by an electron-attracting group at the ortho or para position show higher reactivity than substrates with an electron-donating function.
Keywords :
Catalytic reaction , cyanosilylation , cyanotrimethylsilane , hetero , substituted ketones , lithium chloride , silylatedcyanohydrins
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
