Title of article :
A Silica-Supported Copper(I) Catalyzed Sonogashira Coupling Reaction
Author/Authors :
Zhang, Liyuan Huaibei Coal Teachers College - Department of Chemistry, China , Li, Pinhua Huaibei Coal Teachers College - Department of Chemistry, China , Wang, Lei Huaibei Coal Teachers College - Department of Chemistry, China , Wang, Lei Chinese Academy of Sciences - Shanghai Institute of Organic Chemistry - State Key Laboratory of Organometallic Chemistry, China
Abstract :
An immobilization of copper(I) in organic–inorganic hybrid materials catalyzed Sonogashira coupling reaction was developed. Terminal alkynes reacted with aryl iodides and aryl bromides in the presence of 3-(2-aminoethylamino)propyl functionalized silica gel immobilized copper(I) catalyst, triphenylphosphineand potassium carbonate in DMF. The reactions generated the corresponding cross-coupling products in goodto excellent yields. Furthermore, silica-supported copper was recovered and recycled by a simple filtration ofthe reaction solution and used for six consecutive trials without decreases in activity.
Keywords :
Sonogashira coupling reaction , organic–inorganic hybrid material , immobilization of copper(I) , heterogeneous catalyst
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
