Author/Authors :
Miao, Wei Wu Xi PharmaTech Co. Ltd., China , Miao, Wei Central South University of Forestry and Technology, China , Jia, Lanqi Wu Xi PharmaTech Co. Ltd., China , Zhang, Zhiliu aWu Xi PharmaTech Co. Ltd., China , Donga, Jingcha aWuXi PharmaTech Co. Ltd., China , Shia, Yifeng Wu Xi PharmaTech Co. Ltd., China , Ma, Rujian Wu Xi PharmaTech Co. Ltd., China , Tang, Suhan Wu Xi PharmaTech Co. Ltd., China , Chen, Shu-Hui Wu Xi PharmaTech Co. Ltd., China , Li, Ge Wu Xi PharmaTech Co. Ltd., China
Abstract :
We present herein a general method for the preparation of chiral terminal olefin bearing long chain α-amino acids via the following three-step sequence starting from (S)-N-Boc-2-pyrrolidone-5-carboxylic acid: (1)opening of the γ-lactam ring by an organometallic reagent, (2) keto reduction, and (3) ester hydrolysis.
Keywords :
Synthesis , optically pure α , amino acid , long chain , terminal olefin , BILN , 2061.
