Title of article :
A Practical Synthesis of Thio-Bisphosphonic Acids For the Treatment of Arthritis, Based on the Chemistry of Tetraethyl Methylene-1,1-Bisphosphonate
Author/Authors :
Abdou, Wafaa M. National Research Centre - Pesticide Chemistry Dept, Egypt , Khidre, Maha D. National Research Centre - Pesticide Chemistry Dept, Egypt , Sediek, Ashraf A. National Research Centre - Pesticide Chemistry Dept, Egypt
Abstract :
The synthesis of novel S-bisphosphonates (S-BPs) by two different approaches is described. Hydrolysis of the resulted BPs with conc. HCl afforded the corresponding thio-bisphosphonic acids. The properties of these compounds in the rat adjuvant model of arthritis, and the synthetic routes to these and related compounds are detailed.
Keywords :
Cyclic , and acyclic cis , disulfides , Shiff , bases , Sulfur , containing bisphosphonic acids , Arthritis , Inflammatory
Journal title :
letters in organic chemistry
Journal title :
letters in organic chemistry
