Author/Authors :
Wu, Xiaochun Sichuan University - West China School of Pharmacy, China , Wu, Xiaochun Sichuan Normal University - College of Chemistry and Material, China , Wu, Yong Sichuan University - West China School of Pharmacy, China , Hai, Li Sichuan Universit - West China School of Pharmacy, China , Bao, Ying Sichuan University - West China School of Pharmacy, China
Abstract :
A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 undermild condition in moderate yield.
Keywords :
Cholesterylated carboxylic acid , oligo(ethylene glycols) , targeting ligand , gene delivery
