Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid

(R)-Arundic acid 15 was prepared in a simple manner and with absolute optical purity via Cu and Femediated and Luche’s crotylation of 1 with bromides 6a,b. Co wasn’t a good mediator for these crotylation reactions. The stereoselectivity for all crotylations were similar producing mainly 7b, c, besides a small amount of 7a.