Title of article
Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid
Author/Authors
Goswami, Dibakar Bhabha Atomic Research Centre - Bio-Organic Division, India , Chattopadhyay, Angshuman Bhabha Atomic Research Centre - Bio-Organic Division, India
From page
922
To page
925
Abstract
(R)-Arundic acid 15 was prepared in a simple manner and with absolute optical purity via Cu and Femediated and Luche’s crotylation of 1 with bromides 6a,b. Co wasn’t a good mediator for these crotylation reactions. The stereoselectivity for all crotylations were similar producing mainly 7b, c, besides a small amount of 7a.
Keywords
Alzheimer disease , arundic acid , (R) , 2 , 3 , cyclohexylideneglyceraldehyde , crotylation , propargyl alcohol , stereoselectivity , ozonolysis , enantiopurity.
Journal title
letters in organic chemistry
Journal title
letters in organic chemistry
Record number
2718101
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