Author/Authors :
Elfeky, Mariem A Department of Pathology - Faculty of Medicine - Zagazig University, Zagazig, Egypt , Harb, Ola A Department of Pathology - Faculty of Medicine - Zagazig University, Zagazig, Egypt , Shafaay, Basant Sh El Department of Clinical Oncology and Nuclear Medicine - Faculty of Medicine - Zagazig University, Zagazig, Egypt , Obaya, Ahmed A Department of Clinical Oncology and Nuclear Medicine - Faculty of Medicine - Zagazig University, Zagazig, Egypt , Awd, Amr A Department of Gynecology and Obstetrics - Faculty of Medicine - Zagazig University, Zagazig, Egypt , Alkilany, Mohamed M Department of General Surgery - Faculty of Medicine - Zagazig University, Zagazig, Egypt , Gertallah, Loay M Department of General Surgery - Faculty of Medicine - Zagazig University, Zagazig, Egypt
Abstract :
Background: Evaluation of cancer cervix prognosis is highly needed for novel
targeted therapy and improved outcomes. Nucleolar and spindle associated protein 1
(NUSAP1) is a novel biomarker that has roles in spindle formation and mitotic
progression. Maternal embryonic leucine zipper kinase (MELK) is involved in cell
cycle control and carcinogenesis. The L1 cell adhesion molecule (L1-CAM) plays an
essential role in cell migration. This study aimed to investigate NUSAP1, MELK,
and L1CAM immunohistochemical expression in cancer cervix tissues and detect
their prognostic roles.
Method: In this prospective cohort study, we evaluated NUSAP1, MELK, and
L1CAM expressions of sections from 62 cervical carcinoma cases using immunohis-
tochemistry.
Results: NUSAP1, MELK, and L1CAM expression correlated with tumor high
grade, advanced FIGO stage, poor survival rates, and higher recurrence rate after
successful therapy (P<0.001).
Conclusion: Expression of NUSAP1, MELK, and L1CAM in cancer cervix was
associated with poor prognosis.
Keywords :
Cancer cervix , Immunohistochemistry , Prognosis , NUSAP1 , MELK , L1CAM
