Author/Authors :
CHIRAGH, SADIA King Edward Medical University - Department of Pharmacology, Pakistan , CHIRAGH, SADIA Fatima Jinnah Medical College, Pakistan , BEGUM, ALMAS King Edward Medical University - Department of Pharmacology, Pakistan , BEGUM, ALMAS Fatima Jinnah Medical College, Pakistan , KARIM, SAMINA King Edward Medical University - Department of Pharmacology, Pakistan , KARIM, SAMINA Fatima Jinnah Medical College, Pakistan
Abstract :
There is a continuous search for new prokinetic agents for use in gastro intestinal hypomotility. Erythromycin, a macrolide, is one of them. In this study we observed effect of other macrolides, i.e. clarithromycin and azithromycin on rabbit duodenum and compared with that of neostigmine. Both these drugs produced significant prokinetic effect with EC50 0.4 ,g/ml and 0.29 ,g/ml respectively. Effect of clarithromycin was well sustained as compared to that of azithromycin, so it seemed to be a better prokinetic agent
