IMMUNOREACTIVITY OF PROLIFERATING CELL NUCLEAR ANTIGEN IN TRANSITIONAL CELL CARCINOMA OF URINARY BLADDER

This is a descriptive study designed to evaluate Proliferating cell nuclear antigen (PCNA) in transitional cell carcinoma. A total of fifty per urethra resected bladder tumour samples (TUR BT) were collected from Mayo Hospital and Services Hospital, Lahore and processed for H E and PCNA stain. The grading of tumours were made on H E stain. While Proliferating cell nuclear antigen labeling index was recorded for each case. The mean PCNA labeling index was significantly higher in grade III when compared with tumours of grade II. (p 0.001) carci- noma. Similarly mean PCNA labeling index was significantly higher (p 0.05) in patients hav- ing duration of symptoms up to 3 month when compared with the patients having longer duration of symptoms. The mean PCNA labeling index had significantly higher value in high grade tumours as compared to low grade tumours (p 0.001). Although determination of PCNA labeling index is costly yet it has significant role in tumour grading.