Author/Authors :
ZAMAN, SAFEER Shaikh Zayed Federal Postgraduate Medical Institute - Department of Physiology, Pakistan , ZULFIQAR, SIBGHA Shaikh Zayed Federal Postgraduate Medical Institute - Department of Physiology, Pakistan , KHAN, M. SHOAIB Bannu Medical College - Department of Biochemistry, Pakistan
Abstract :
Clomiphene citrate is a synthetic nonsteroidal drug that acts as an antioestrogen and com- petitively binds to oestrogen receptors in the hypothalamus and pituitary. This blocks the action of the normally low levels of oestrogen on the male hormone axis and results in increased sec- retion of GnRH, FSH and LH. The enhanced output of these hormones increases testosterone production and sperm production. A non randomised clinical trial was conducted in a sample of 21 idiopathic oligospermic men from local population with a mean age of 27.75 ± 4.13 years, to evaluate the effects of clomiphene citrate in a dose of 100mg/day for five days, on serum testo- sterone, serum FSH, semen volume, sperm density, and total sperm motility. After clomiphene citrate therapy, mean serum testosterone level showed highly significant increase (p 0.05), mean serum FSH level showed significant increase (p 0.1). Semen analyses were done at periodic intervals, 1st at day 1 i.e. before the 1st dose of clomiphene citrate, 2nd at 6th day i.e. 24 hours after the last dose of clomiphene citrate, and 3rd at 74th day of the trial. Clomiphene citrate administration resulted in statistically significant increase in the mean semen volume at day 6 (p 0.05), increase in the sperm density at day 74 (p 0.05), and increase in the total sperm motility at day 6 (p 0.05).
