Author/Authors :
ZULFIQAR, AYESHA University of Health Sciences - Department of Pathology, Pakistan , NAGI, A. H. University of Health Sciences - Department of Pathology, Pakistan , NASIM, NADIA University of Health Sciences - Department of Pathology, Pakistan
Abstract :
Background: Oral squamous cell carcinoma is one of the most common and devastating oral cancer. It is the sixth most common tumour worldwide with almost 90,000 cases reported annually. Its incidence is alarmingly increasing in many South Asian countries owing to the increase in areca nut, betel quid and tobacco chewing habits among vast population of this region. Objective: To see the clinical and histopathological pattern of oral squamous cell carcinoma in a tertiary care hospitals of Pakistan. Materials and Methods: This was a descriptive study. 39 patients of primary oral squamous cell carcinoma were studied from two tertiary care hospitals of Punjab namely Mayo Hospital Lahore and Allied Hospital Faisalabad. Detailed clinical histories of the patients were recorded. The histopathologic examination on the specimens removed was performed using haematoxylin and eosin (H E) stain. Clinical data included age, sex of the patient and intraoral site of cancer. Histopathological data included the grade of Squamous cell carcinoma. The grading was done using Anneroth grading system. The data was analysed on SPSS 18. Results: In our study the patients with squamous cell carcinoma had a mean age of 50.36 ± 1.98 years with equal prevalence in both genders. It was observed that SCC was most commonly arising from tongue (23.1%) followed by lip mucosa (20.5%) and buccal mucosa (12.8%). Most of the cases were moderately differentiated (51.3%), whereas the remaining were well and poorly differentiated. A very strong association (p = 0.001) was found between the site and grade of tumour using Fisher’s exact test. Almost all the tumours on sublingual mucosa especially those arising from floor of the mouth were poorly differentiated.
