RELATIONSHIP OF HYPOADIPONECTINEMIA WITH GLYCEMIC STATUS AND LIPID PROFILE IN TYPE 2 DIABETIC WOMEN WITH AND WITHOUT CORONARY HEART DISEASE

Objective: To find circulating adiponectin concentration in type 2 diabetic women with and without coronary heart disease and to establish a relationship of adiponectin level with glycemic status and lipid profile of these women. Study Design / Methods: It was a cross – sectional analytical study. The study consisted of twenty four healthy females, twenty six type 2 diabetic females and twenty four type 2 diabetic females having coronary heart disease. All the participants were selected randomly. Fasting blood samples were obtained from the participants and were analyzed for serum adiponectin level, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and very low density lipoprotein cholesterol (VLDL-C). Results: Type 2 diabetic females with and without coronary heart disease revealed significantly low (p value 0.001) serum adiponectin level and significantly high (p value 0.001) FBG and HbA1c level as compared to the healthy females. Female diabetic participants with and without coronary heart disease showed significant negative association of adiponectin with FBG (r -0.874, p = 0.01); (r -0.497, p = 0.010), HbA1c (r -0.937, p = 0.01); (r -0.814, p = 0.01), total cholesterol (r -0.423, p = 0.039); (r -0.733, p = 0.01) and triglycerides (r -0.669, p = 0.01); (r -0.790, p = 0.001). A significant positive association of adiponectin was sun in all three groups i.e healthy females (r 0.988, p = 0.01), type 2 diabetic females with coronary heart disease (r 0.775, p = 0.01) and type 2 diabetic females without coronary heart disease (r 0.908, p = 0.01). Conclusion: Serum adiponectin level is markedly reduced in type 2 diabetic females with and without coronary heart disease. Moreover, hypoadiponectinemia in these women is related with un-controlled glycemic status and abnormal lipid level in the circulation.