EFFECT OF CARDIOPULMONARY BYPASS ON LIVER FUNCTION IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING

Objective: To see the effects of CPB and aortic cross clamp time on postoperative liver function after coronary artery bypass grafting. Methodology: A non randomized prospective study of 100 patients, selected for CABG with normal liver function, was carried out. A questionnaire was used as a research tool. Demographic factors, preoperative, intra operative and post operative variables were evaluated. Patients were divided into two groups according to aortic cross clamp time (patient with aortic cross clamp time 50 minutes and patients with aortic cross clamp time ≥ 50 minutes). SPSS v.16.0 was used to analyze the data. p-value ≤ 0.05 was considered as significant. Results: Mean age of our patients was 55.6 ± 8.1 years and there was an overall male predominance (78% males and 22% females). There was significant difference between pre and post-operative bilirubin and alkaline phosphatase (ALP) levels as p-value was 0.05. While no significant differences in pre and post-operative levels of liver enzymes were found with respect to aortic cross clamp time in both groups. Conclusion: Our study showed that there is no significant effect of aortic cross clamp time on post- operative liver enzyme (AST ALT) levels. However there were significant differences between pre and post operative values of bilirubin and ALP.