Author/Authors :
ahtesham, k. university of health sciences - postgraduate medical institute, ameer-ud-din medical college - department of histopathology, Pakistan , ahtesham, k. sharif medical dental college - department of pathology, pakistan , jaffer, r. services institute of medical sciences - department of pathology, pakistan , jaffer, r. university of health sciences - postgraduate medical institute, ameer-ud-din medical college - department of histopathology, Pakistan , imran, a.a. allama iqbal medical college - department of pathology, Pakistan , imran, a.a. university of health sciences - postgraduate medical institute, ameer-ud-din medical college - department of histopathology, Pakistan , salaria, s.m. azad kashmir medical college - department of pathology, Pakistan , salaria, s.m. university of health sciences - postgraduate medical institute, ameer-ud-din medical college - department of histopathology, Pakistan , haseeb, m.t. university of health sciences - postgraduate medical institute, ameer-ud-din medical college - department of histopathology, Pakistan , haseeb, m.t. sheikh zayed medical college - department of pathology, Pakistan
Abstract :
Introduction: Breast cancer is the most common malignancy and a leading cause of death in women throughout the world. It is the most frequently reported malignancy and a major cause of cancer morbidity and mortality in Pakistan as well. Objective: To compare the Argyrophilic nucleolar organizer regions size and dispersion in estrogen receptor positive and ER-ve tumors of invasive ductal carcinoma of breast. Materials and Methods: Fifty cases of invasive ductal carcinoma of breast diagnosed on trucut, core biopsy/incision/excision were collected from Lahore General Hospital, Lahore. The slides prepared were stained with H E, AgNOR, and ER immunostains. Results: The mean age of the patients was 46.84 years ± 11.8 SD. AgNOR size and dispersion were significantly of higher grade (p = 0.001 and p 0.05) in ER-ve tumors than ER+ve tumors. Conclusion: It is concluded that AgNOR size and dispersion correlateinversely with ER status in invasive ductal carcinoma of breast and the results are statistically significant.
