Title of article :
Association of Human Parvovirus B19 with Papillary Thyroid Carcinoma and its Relationship with Tumor Staging and Pathologic Features
Author/Authors :
Archin Dialameh, Pardisa Endocrinology and Metabolism Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Saki, Forough Endocrinology and Metabolism Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Monabbati, Ahmad Department of Pathology - Shiraz University of Medical Sciences, Shiraz, Iran , Dehghanian, Amirreza Department of Pathology - Shiraz University of Medical Sciences, Shiraz, Iran , Valibeigi, Behnaz Department of Pathology - Shiraz University of Medical Sciences, Shiraz, Iran , Soveid, Mahmood Endocrinology and Metabolism Research Center - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Background: Papillary thyroid carcinoma (PTC) is the most prevalent form of
thyroid cancer. In some studies, parvovirus B19 (PVB19) infection was involved in
the pathogenesis of thyroid diseases such as Graves’ disease, Hashimoto thyroiditis,
and thyroid cancer. PVB19 induces chronic inflammation in thyroid, which can lead
to carcinogenesis through the effect of inflammatory mediators. The association of
PVB19 with PTC tumorigenesis is still a matter of controversy. We evaluated the
correlation of PVB19 with PTC and, for the first time, pathologic features.
Method: This cross-sectional retrospective study focused on the thyroid specimens
of 82 patients with PTC and 77 patients with benign thyroid nodules. We conducted
the present study from March 2014 to November 2017 in the hospitals affiliated with
Shiraz University of Medical Sciences, Shiraz, Iran. We evaluated the presence of
PVB19 DNA by nested polymerase chain reaction method in PTC, adjacent non-
malignant tissues, and benign thyroid nodules. PVB19 positivity was also compared
between PTC and two other groups. We further investigated the association of
pathologic features and tumor staging with PVB19 positivity.
Results: Of the patients, 81% were female. We detected PVB19 positivity in 9.8%
of PTC specimens and 0.01 of adjacent non-malignant tissues (P=0.016). None of
the benign thyroid nodule specimens had PVB19 DNA, and they were significantly
different from PTC specimens (P=0.007). There was no significant correlation between
PVB19 positivity and tumor stages (P=0.988) and histologic types (P=0.560).
Conclusion: This research, similar to some other studies, showed a significant
association between PTC and PVB19 positivity. For the first time, we showed that no
significant relationship existed between PVB19 positivity and tumor stages and
histologic types. Further investigations are needed to evaluate the relationship between
this virus and PTC.
Keywords :
Human parvovirus B19 , Papillary thyroid carcinoma , Thyroid cancer
Journal title :
Middle East Journal of Cancer (MEJC)
