Title of article :
N-Chromosome Royal Jelly, Propolis and Bee Pollen Supplementation Improve the Clinical Conditions of COVID-19 Patients: A Randomized Controlled Trial
Author/Authors :
Abedini ، Atefeh Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Shafaghi ، Shadi Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Ameri Ahmad ، Zahra Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Javanmardi ، Elmira Department of Cardiovascular Medicine - Heart Center, Ayatoullah Mousavi Hospital - Zanjan University Medical School , Ghorbani ، Fariba Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases - Shahid Beheshti University of Medical Sciences , Sharif-Kashani ، Babak Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Naghashzadeh ، Farah Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Shafaghi ، Masoud Strategic Planning and Executive Office Manager of International Federation of Inventors’ Associations IFIA , Moshirpour ، Melina Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Noorali ، Sima Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Hakimian ، Hoda Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Keshmiri ، Mohammad Sadegh Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Fazlzadeh ، Aylar Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences
Abstract :
Royal jelly, propolis, and bee pollen are used for different purposes all around the world according to their anti-inflammatory, antioxidant, and antimicrobial activities. Given that Coronavirus 2019 (COVID-19) is a viral condition accompanied by a dysregulated inflammatory response in the body, we intend to evaluate the effects of natural supplementations on the disease course. A randomized, open-label, controlled trial was conducted among 50 definitive cases of COVID-19. These patients were randomly assigned into control and intervention groups. Royal Jelly, propolis, and bee pollen were prescribed to patients in the intervention group (n = 24) in addition to conventional treatment; while the control group only received the standard treatment (n = 26). At the end of the study, functional class improved in both groups, but this change was more pronounced in the intervention group (p 0.05). Moreover, total symptoms duration and the time to return to work were significantly reduced in the intervention group (p 0.05). Although royal jelly, propolis, and bee pollen are not definitive treatments in COVID-19 patients, they can be used as an adjuvant treatment to limit disease symptoms and virus propagation.
Keywords :
Royal jelly , Bee pollen , Propolis , Hyperinflammation , Corona virus disease 2019 (COVID , 19)
Journal title :
Traditional and Integrative Medicine
Journal title :
Traditional and Integrative Medicine
