Synthesis and Characterization of New 1,3,4-Thiadiazole Derivatives Containing Azo Group from Acid Hydrazide and Studying Their Antioxidant Activity

The present report describes the synthesis of new the synthetic route that started by the reaction of acid hydrazide derivatives with ammonium thiocyanate to give compounds 1a-d. 1,3,4-thiadiazole derivatives 2a-d were synthesized by the reaction compounds 1a-d with concentration sulfuric acid. Finally, the reaction 1,3,4-thiadiazole derivatives 2a-d with sodium nitrate and hydrochloric acid in 0-5 °C to form diazonium salt, then diazonium salt reacted with 4-dimethylaminobenzaldehyde to synthesize azo compounds 3a-d. These new synthesized products were characterized by FT-IR, 1H-NMR for some of them and were studied regarding the effect of preparing derivatives on antioxidant activity.