Determination of diosmin and quercetindihydrate through charge transfer interaction with 4-methylamino phenol and normal flow injection system with spectrophotometric detection

In this work, we used normal flow injection analysis for determining two drugs of Quercetindehydrate symbolized as QE and Diosmin symbolized as DSN. The aim was to develop a simple, rapid, less expensive, linear, precise and accurate technique using p-Methylaminophenol Sulfate (MFS) in the presence of an oxidative agent of Sodium per iodate in aqueous medium. After the experimental conditions were passed, ideal conditions were adopted for this work, and the detection of the highest absorption of the two drugs was reached. Detected at the Maximum wavelength, we recorded them (QE= 641 nm and DSN = 665 nm). We studied beaver each drug by flow injection technique chosen concentration rang from (2-160) mg .ml^-1 for QE and DSN with MFS reagent in presence of oxidative agent draw calibration graph which gave a linear relationship with correlation coefficients of 0.9994 and 0.9989, respectively. The sample response time for each drug was 20 seconds for QE and 19 seconds for DSN and the detection limit for the proposed approach was (1.4×10^-5) for QE and DSN, depending on trace drug concentration. The proposed approach was used to study and determine the two suggested medications in injections and tablets with great effectiveness.