Synthesis of disubstituted anisolodipyrone-derived ester compounds: The search for new bioactive candidates

In this study, ketone di-α-carboxylic acid prepared from the interaction between anhydrous citric acid and strong inorganic acid was included in the Pechmann-related condensation to create a novel disubstituted anisolodipyrone building unit (MSY1). This precursor was interacted with different monofunctionalized phenols to afford six disubstituted anisolodipyrone-derived ester compounds, marked here as MSY2-MSY7. The molecular chemo-skeletal structures of the precursor and its derived compounds were identified spectrometerically. The potential of these compounds to present bioactive candidates was inspected in vitro through evaluation of their capacity to act as antiproliferative, antimicrobial, and glucose-regulating applicants. The authors found that our compounds, notably MSY4, have broad potent-to-moderate antiproliferative properties with a tiny harmful impact on normal cells. Also, these compounds showed positive antibacterial properties, particularly MSY2, MSY5, and MSY1, for anaerobic, aerobic gram-negative bacteria, and filamentous fungi, correspondingly. This positivity is endorsed by our chemicals comparative safety in terms of normal flora bacteria. Moreover, MSY2 and MSY3 have the strongest suppression influence on the test glucose-regulating enzymes, with a moderate effect attributed to the other compounds. Based on the findings, the researchers concluded that the synthetic candidates might provide a type of platform, potentially opening up new options for the discovery of novel pharmaceutically active applicants.