Author/Authors :
Khorrami, Mohammad Sadegh Department of Medical Genetics and Molecular Medicine - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran - Student Research Committee - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran - Metabolic Syndrome Research center - Mashhad University of Medical Sciences, Mashhad, Iran , Sadabadi, Fatemeh Metabolic Syndrome Research center - Mashhad University of Medical Sciences, Mashhad, Iran , Pasdar, Alireza Department of Medical Genetics and Molecular Medicine - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Safarian-Bana, Hamide Metabolic Syndrome Research center - Mashhad University of Medical Sciences, Mashhad, Iran , Amerizadeh, Forouzan Department of Medical Genetics and Molecular Medicine - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran - Student Research Committee - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Esmaeily, Habibollah Department of Epidemiology and Biostatistics - School of Health - Mashhad University of Medical Sciences, Mashhad, Iran , Moohebati, Mohsen Metabolic Syndrome Research center - Mashhad University of Medical Sciences, Mashhad, Iran , Heidari-Bakavoli, Alireza Metabolic Syndrome Research center - Mashhad University of Medical Sciences, Mashhad, Iran , Ferns, Gordon Brighton & Sussex Medical School - Division of Medical Education - Falmer - Brighton, Sussex, UK , Ghayour-Mobarhan, Majid Metabolic Syndrome Research center - Mashhad University of Medical Sciences, Mashhad, Iran , Avan, Amir Department of Medical Genetics and Molecular Medicine - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran - Student Research Committee - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran - Metabolic Syndrome Research center - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Background: Cardiovascular disease is one of the most common causes of morbidity and mortality
worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be
associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The
objective of this study was to investigate the association between the rs599839 polymorphism of the Proline
and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part
of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort.
Methods: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled
as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based
method.
Results: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95%
CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for
GG genotype data.
Conclusions: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased
risk of CVD in a representative population-based cohort, demonstrating further functional analysis to
discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.
