Title of article :
The effect of adding hyaluronic acid to calcium phosphate on periapical tissue healing following periradicular surgery in dogs
Author/Authors :
Segari, Wafaa Ahmed Omar Cairo University - Faculty of Oral and Dental Medicine - Department of Endodontics, Egypt , Abd El Khalek Radwan, Dalia Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Surgery, Egypt , Abd El Hamid, Mohamed Ayad Cairo University - Faculty of Veterinary Medicine, Egypt
From page :
122
To page :
129
Abstract :
Objective: This study aimed to evaluate the effect of adding exogenous hyaluronic acid (HA) to Beta-tricalcium phosphate (CP) on osseous tissue healing of induced apical lesions following periradicular surgery in a dog model. Methods: In the first and second sessions, periapical lesions were induced by exposing pulp cavities of selected teeth for 7 days then sealing them with glass ionomer for 60 days. Root canals were then cleaned, shaped and obturated. Surgical treatment included buccal osteotomy to expose the root apex and root-end resection and filling. Osteotomy cavities were randomly allocated to two study groups 12 samples each according to the graft materials; CP or combination of HA and CP. The graft materials were prepared and applied in each animal in alternate quadrant in a randomizedmanner. Animals were sacrificed after 60 days and bone treated cavities were prepared for histological study and histomorphometric analysis for the area percentage of new bone tissue and trabecular bone thickness. Results: All samples displayed signs of regeneration as newly formed bone tissue and fibrovascular connective tissue within the treated cavity sites with complete resorption of the implemented materials. The newly formed bone consisted mainly of osteoid bone trabeculae with some more mature dense bone present at the periphery of cavity site. There was no significant difference in the percentage of newly formed bone tissue (P 0.05) and bone trabeculae thickness (P 0.05) between the two study groups. Conclusions: Addition of exogenous HA to CP after periradicular surgery did not improve the histological outcome of osseous tissue healing in a dog model.
Keywords :
Hyaluronic acid , Hyaluronan , Calcium phosphate , Bone grafts , Alloplasts , Periapical lesion induction
Journal title :
Tanta Dental Journal
Journal title :
Tanta Dental Journal
Record number :
2720704
Link To Document :
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