The effect of Nanobone® in combination with platelet rich fibrin on bone regeneration following enucleation of large mandibular cysts

Objective: This study was performed to evaluate the healing kinetics of combining Nanobone® and PRF following enucleation of large mandibular cysts. Materials and methods: 15 patients with large mandibular odontogenic cysts were treated by enucleation and grafting the bone defects by a combination of Nanobone® and PRF. Post-operative clinical and radiographic follow-up were performed. The change in the surface area and bone density of the bone defects was measured using cone beam computerized tomography (CBCT) immediately post-operatively, and after 6 and 9 months. Results: Accelerated wound healing was observed in all cases without any signs of post-operative complications. On the 9th month post-operatively the surface area decreased by 51% and there was an increase of 50.8% in bone density. Conclusion: Nanobone®/PRF combination accelerated bone healing and improved the quality and quantity of regenerated bone.