Author/Authors :
naz, f. aligarh muslim university - department of zoology, human genetics and toxicology laboratory,section of genetics, India , jyoti, s. aligarh muslim university - department of zoology, human genetics and toxicology laboratory,section of genetics, India , akhtar, n. aligarh muslim university - medical college - department of obstetrics and gynecology, India , afzal, m. aligarh muslim university - department of zoology, human genetics and toxicology laboratory,section of genetics, India , siddique, y.h. aligarh muslim university - department of zoology, human genetics and toxicology laboratory,section of genetics, India
Abstract :
Synthetic progestins and estrogens have been reported to be toxic in various experimental models. Their prolonged use has been reported to induce cancer in humans. In the present study the effects of oral contraceptives were studied among users using chromosomal aberrations,sister chromatid exchanges and DNA damage as a parameter,in cultured human peripheral blood lymphocytes. The study was performed on 25 women (users) and 25 age match controls. No significant difference was observed in chromosomal aberrations and DNA damage. A significant increase was observed in sister chromatid exchanges (SCEs) Cell among users. The results obtained and the risk of oral contraceptives (OCs) genotoxicity have been discussed. © 2012.
Keywords :
Chromosomal aberrations , DNA damage , Human lymphocytes , Oral contraceptives , Sister chromatid exchanges
