Lower HOMA-β values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel,subfamily J,member 11 (KCNJ11) gene

Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease involving both genetic and also environmental factors. Potassium inwardly-rectifying channel,subfamily J,member 11 (KCNJ11) gene,an ATP-sensitive potassium channel-coding gene,contributes to insulin secretion. Objectives: This research aimed to investigate E23K polymorphism in KCNJ11 gene and insulin secretion in individuals with family history of T2DM (cases) and without family history of T2DM (controls). Method: This research was a case-control study involving 34 cases and 34 controls. E23K polymorphism of KCNJ11 was detected with PCR-RFLP. All of the obtained data were statistically analyzed with T-test,Mann-Whitney U-test,Chi-Square and One-Way ANOVA. Result: Frequency of AA genotype in individuals with family history of T2DM (41%) was higher than in individuals without family history of T2DM (6%) (p = 0.001). Frequency of A allele in individuals with family history of T2DM (68%) was higher than in individuals without family history of T2DM (38%) (p = 0.001). The risk of A allele in individuals with family history of T2DM was 3 times higher than in individuals without family history of T2DM (p = 0.001,OR 3.38,CI 95% 1.67-6.84). Homeostasis Model Assessment β (HOMA-β) values of AA genotype (85.44%. ±. 39.55) were lower than that of GA (212.20%. ±. 79.30) and GG (254.00%. ±. 61.98) genotypes (p = 0.000). Conclusion: The risk of having A allele in individuals with family history of T2DM is higher than that in individuals without family history of T2DM. HOMA-β values of AA genotype are lower than that of GA and GG genotypes. © 2015 The Authors. Production and hosting by Elsevier B.V.