Author/Authors :
Altinmakas , Emre Department of Radiology - Koc University School of Medicine, Istanbul, Turkey. , Guler , Begum Department of Medicine - Koc University School of Medicine, Istanbul, Turkey. , Copur, Sidar Department of Medicine - Koc University School of Medicine, Istanbul, Turkey. , Siriopol , Dimitrie Nephrology Clinic - Dialysis and Renal Transplant Center - ‘C.I. PARHON’ University Hospital and ‘Grigore T. Popa’ University of Medicine, Iasi, Romania , A. Sag, Alan Division of Vascular and Interventional Radiology - Department of Radiology - Duke University Medical Center, Dur- ham, USA. , Guneyli, Serkan Department of Radiology - Koc University School of Medicine, Istanbul, Turkey. , Dogan, Hakan Department of Radiology - Koc University School of Medicine, Istanbul, Turkey. , Afsar ,Baris Department of Medicine - Division of Nephrology - Suleyman Demirel University School of Medicine, Isparta, Turkey. , Balik, Emre Department of General Surgery - Koc University School of Medicine, Istanbul, Turkey. , Covic, Adrian Nephrology Clinic - Dialysis and Renal Transplant Center - ‘C.I. PARHON’ University Hospital and ‘Grigore T. Popa’ University of Medicine, Iasi, Romania , J. Johnson , Richard Division of Renal Diseases and Hypertension - School of Medicine - University of Colorado Denver, Aurora, CO, USA. , Kanbay, Mehmet Department of Medicine - Division of Nephrology - Koc University School of Medicine, Istanbul, Turkey
Abstract :
BACKGROUND
Metabolic syndrome affects 35% of the adult population in developed countries associ-
ated with non-alcoholic steatohepatitis, insulin resistance, and cardiovascular events. Fatty
infiltration of the pancreas, or pancreatic steatosis, is a risk factor for acute pancreatitis,
pancreatic malignancies, and diabetes mellitus, yet its relationship with metabolic syndrome
is not well defined.
METHODS
We performed a single-centered retrospective observational study of 322 healthy
subjects (subjects volunteering to be kidney transplant donors, mean age=46.3±13.5,
163 men and 159 women) in the last 2 years (July 2018-February 2020) from our in-
stitution. Pancreatic steatosis and hepatosteatosis were confirmed by computed tomog-
raphy.
RESULTS
Pancreatic steatosis was present in 26.3% (85/322) of the subjects, and this finding
correlated with age, body mass index (BMI), male sex, a family history of diabetes,
creatinine, cystatin C, uric acid, low-density lipoprotein (LDL) cholesterol, triglyc-
erides, glycemia, hemoglobin, transverse body diameter, and subcutaneous fat thick-
ness levels by univariable logistic regression. On multiple linear regression only age
(95% CI 1.01, 1.06), BMI (95% CI 1.01, 1.19), male sex (95% CI 1.49-5.99), uric
acid (95% CI 1.01, 1.76), and subcutaneous fat thickness levels (95% CI 1.21-2.36)
remained independently associated with pancreatic steatosis.
CONCLUSION
Pancreatic steatosis is common and associated with obesity, elevated serum uric acid, sub-
cutaneous fat thickness, and male sex. Future studies are needed to evaluate if there are specific
clinical consequences to the presence of pancreatic steatosis.
