Title of article :
The protective role of l-Carintine and vitamin E on gamma irradiated rat’s tongue mucosa
Author/Authors :
El-Rouby, D.H Oral Pathology Department - Faculty of Dentistry - Cairo University, Egypt , El-Batouti, A.A Health Radiation Research Department - National Centre for Radiation Research and Technology (NCRRT) - Atomic Energy Authority, Cairo, Egypt
Abstract :
Background: The aim of this study was to investigate the antioxidant effect of L-carnitine (LC) against gamma-irradiation-induced oxidative damage in tongue of albino rats after total body irradiation with a single dose of 6 Gy. Materials and Methods: 48 adult rats were randomly divided into 3 groups of
16 animals each. Group I was irradiated with a single dose of 6 Gy. Group II
received a daily i.p. injection of LC (250 mg/kg, i.p.) for 5 consecutive days and
1 h after the last dose, rats were irradiated with a single dose (6 Gy). Group III
received a daily i.p. injection of LC (250 mg/kg, i.p.) and Vitamin E 40 mg/kg
intramuscular daily for 5 consecutive days and 1 h after the last dose, rats
were irradiated with a single dose (6 Gy). At day 7 and day 14 after treatment
exposure, 8 rats from each group were sacrificed. Results: Administration of
LC resulted in attenuation of the histological changes noticed in irradiated
rats. The number of p53 positive nuclei significantly decreased in rats
receiving LC alone or in combination with VE. Conclusion: LC and VE has
shown positive effect in minimizing the epithelial atrophy of tongue mucosa after radiotherapy, which was emphasized by decreasing apoptotic activity in these tissues.
Keywords :
Gamma irradiation , tongue mucosa , L-carintine , vitamin E
Journal title :
International Journal of Radiation Research
