Title of article :
Chitosan Nanoparticles Containing Cinnamomum verum J.Presl Essential Oil and Cinnamaldehyde: Preparation, Characterization and Anticancer Effects against Melanoma and Breast Cancer Cells
Author/Authors :
Khoshnevisan ، Kamyar Department of Tissue Engineering and Applied Cell Sciences - Medical Nanotechnology and Tissue Engineering Research Center, School of Advanced Technologies in Medicine - Shahid Beheshti University of Medical Sciences , Alipanah ، Hiva Department of Physiology - School of Medicine - Fasa University of Medical Sciences , Baharifar ، Hadi Department of Medical Nanotechnology - Applied Biophotonics Research Center - Islamic Azad University, Science and Research Branch , Ranjbar ، Negar Department of Medicine - School of Medicine - Fasa University of Medical Sciences , Osanloo ، Mahmoud Department of Medical Nanotechnology - School of Advanced Technologies in Medicine - Fasa University of Medical Sciences
Abstract :
Cancer is the second leading cause of death worldwide, and due to the emergence of resistance to synthetic drugs in different cancers, developing new green drugs have become crucial. In this study, chitosan nanoparticles containing Cinnamomum verum J.Presl essential oil and cinnamaldehyde (major ingredient) were first prepared. The obtained nanoparticles were then characterized using Dynamic Light Scattering (DLS), Transmission electron microscopy (TEM), and Attenuated Total Reflection-Fourier Transform InfraRed (ATR-FTIR). After that, anticancer effects of the as-prepared nanoparticles were investigated. IC50 values of chitosan nanoparticles containing the essential oil were observed at 79 and 112 μg/mL against A-375 and MDA-MB-468 cells, respectively. These values for chitosan nanoparticles containing cinnamaldehyde were obtained at 135 and 166 μg/mL. The results of the current study indicated that chitosan nanoparticles containing C. verum essential oil can inhibit the growth of human melanoma (A-375) and breast cancer (MDA-MB-468) cells.
Keywords :
Chitosan , Cinnamaldehyde , Cinnamomum zeylanicum Blume , Essential oils , Anticancer activity
Journal title :
Traditional and Integrative Medicine
Journal title :
Traditional and Integrative Medicine
