Title of article :
Gene Activation as a Cell Protection Mechanism Against Gamma-Ray radiation
Author/Authors :
Nikzamir, Abdolrahim Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rezaei Tavirani, Mostafa Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Razzaghi, Zahra Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rostami-Nejad, Mohammad Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hamdieh, Mostafa Department of Psychosomatic - Taleghani Hospital - Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Arjmand, Babak Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular-Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
ntroduction: Gamma radiation is accompanied by prominent biological effects and damages. Cell
proliferation and tumorigenesis are highlighted as the main resulted effects of gamma radiation
on cultured cells. This study aims to assess the dysregulated mode of gene function after gamma
radiation in human Jurkat cells.
Methods: Six gene expression profiles from Gene Expression Omnibus (GEO) were analyzed by
GEO2R to find the significant differentially expressed genes (DEGs) via gamma radiation. Action
map analysis was applied to screen the query DEGs.
Results: Among 108 study genes, 20 critical DEGs including AURKA, AURKB, BORA, CCNB1,
CCNB2, CCNF, CDC20, CDCA8, CENPA, CENPE, CENPF, KIF18A, KIF20A, KIF23, BUB1, DLGAP5,
ECT2, PLK1, SGO2, and TPX2 were introduced as down-regulated genes by the gamma ray.
Conclusion: Activators of the introduced critical genes may be the cell protector against gamma
radiation.
Keywords :
Gamma ray , Gene , Action map , Activation , Human Jurkat cell
Journal title :
Journal of Lasers in Medical Sciences
