Author/Authors :
Salari, Abolfazl Cancer Research Center - Cancer Institute of Iran - Tehran University of Medical Sciences, Tehran, Iran , Saeedi, Elnaz Cancer Research Center - Cancer Institute of Iran - Tehran University of Medical Sciences, Tehran, Iran , Hadji, Maryam Cancer Research Center - Cancer Institute of Iran - Tehran University of Medical Sciences, Tehran, Iran , Jalaeefar, Amirmohsen Department of Surgery - Cancer Institute of Iran - Tehran University of Medical Sciences, Tehran, Iran , Zendehdel, Kazem Cancer Research Center - Cancer Institute of Iran - Tehran University of Medical Sciences, Tehran, Iran , Shirkhoda, Mohammad Cancer Research Center - Cancer Institute of Iran - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Background: This study aimed to evaluate the role of lymph node
ratio (LNR) in the prediction of Overal Survival (OS) of patients with
Esophageal Squamous Cell Carcinoma (ESCC).
Methods: Patients with ESCC who underwent radical esophagectomy
and radical lymph node dissection were entered into the study. The
survival rate of patients was determined using the Kaplan–Meier
estimator. Also, the effect of LNR and other variables on the OS of
patients was assessed applying COX proportional hazards regression
model. Based on its mean, LNR was divided into two groups of ≤0.25
and >0.25.
Results: In total, 116 patients were entered into the study. The
univariate and multivariate analyses showed that LNR was an
independent prognostic factor for the prediction of the OS of patients
with ESCC. An increase of LNR more than 0.25 led to an increase in
the mortality risk by 1.57 times. Also, the five-year survival of patients
was 26% with LNR≤0.25 and 5% with LNR>0.25.
Conclusion: LNR can be used as an independent prognostic factor in
determining and predicting the OS of patients with ESCC. There was
a relationship between the increase of this factor and the worsening of
patients’ OS.
