Synthesis of new compounds with seven rings (oxazepine) through the ring closure of Schiff bases with study of biological activity

In this study, Schiff base derivatives were reacted with different cyclic anhydrides to prepare some oxazepine ring derivatives. The Schiff base derivatives containing the 2-mercabto benzothiazole moiety were obtained via the reaction of different aromatic aldehyde with 2-(benzothiazol-2-ylthio) acetohydrazide. Furthermore, 2-(benzothiazol-2-ylthio) acetohydrazide was obtained via the reaction of 2-mercabto benzothiazole with ethyl chloroacetate, and then with hydrazine hydrate. The new synthesized compounds were characterized via spectral data (IR and NMR). The antibacterial activity was studied against the examples of Gram-positive (E. coli) and Gram-negative (Staphylococcus aureus) bacteria, and antifungal against Candida fungal.