Author/Authors :
Arjmand, Babak Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular-Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Rezaei Tavirani, Mostafa Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Razzaghi, Mohammadreza Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rostami-Nejad, Mohammad Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hamdieh, Mostafa Department of Psychosomatic - Taleghani Hospital - Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Nikzamir, Abdolrahim Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Background: Although the application of ultraviolet B (UVB) in phototherapy of human skin is a
common therapeutic method, it is known as a risk factor for skin cancer. This study aims to assess
the role of differentially expressed genes (DEGs) to find the critical one that is mainly responsible for
skin protection against UVB radiation.
Methods: The gene expression profiles of irradiated mice by UVB that issued skin protection
against exposure are extracted from Gene Expression Omnibus (GEO) and analyzed by GEO2R.
The significant DEGs are assessed via gene ontology (GO) analysis and the critical individuals are
investigated via action mapping.
Results: Thirty-eight significant DEGs that provide skin resistance against UVB irradiation were
determined. Among the query DEGs, 26 individuals were related to 43 biological terms. Flt4, F3,
Tspan6, Cblb, and Itgb6 were highlighted as the critical DEGs to promote skin protection against
UVB irradiation.
Conclusion: The finding indicates that Flt4 is the key DEG that is mainly responsible for protecting
skin from UVB exposure.
Keywords :
UVB , Skin , Mouse , Gene ontology , Flt4
