Author/Authors :
Vafaee, Reza Critical Care Quality Improvement Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Safari-Alighiarloo, Nahid Endocrine Research Center - Institute of Endocrinology and Metabolism - Iran University of Medical Sciences, Tehran, Iran , Razzaghi, Zahra Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ansari, Mojtaba Faculty of Medicine - Imam Hosein Hospital - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rostami Nejad, Mohammad Research Institute for Gastroenterology and Liver Diseases - Gastroenterology and Liver Diseases Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hamdieh, Mostafa Department of Psychosomatic - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Mansouri, Vahid Proteomics Research Center, Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: The reversibility of biological processes is an important challenge in the study of
environmental pollutants and also natural and artificial radiation. There are many pieces of evidence
about the reversible and irreversible effects of UV radiation on the human body. Assessment of the
reversibility of UV laser effects on Saccharomyces cerevisiae was the aim of this study.
Methods: Gene expression alteration in S. cerevisiae samples radiated by a 30s UV laser for 15,
30, and 60 minutes post-radiation times were investigated via network analysis to explore time-
dependent reversible alteration in the gene expression profiles of the samples.
Results: 19 differentially expressed genes (DEGs) were identified as targeted genes for the samples
which were harvested 60 minutes after radiation; network analysis revealed no significant alteration
in biological processes.
Conclusion: It can be concluded that the gross effects of the UV laser on S. cerevisiae samples
disappear after 60 minutes of radiation.
Keywords :
Post-radiation time , Network analysis , Saccharomyces cerevisiae , Repair , Radiation
