Author/Authors :
Arjmand, Babak Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular-Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Khodadoost, Mahmood School of Traditional Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Jahani Sherafat, Somayeh Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rezaei Tavirani, Mostafa Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ahmadi, Nayebali Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hamzeloo Moghadam, Maryam Traditional Medicine and Materia Medica Research Center - School of Traditional Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Okhovatian, Farshad Physiotherapy Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran. , Rezaei Tavirani, Sina Proteomics Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Introduction: One of the chemoradiotherapy (CRT) side effects is oral mucositis (OM). Since
photobiomodulation therapy (PBMT) is a public method for the repair process, in the present study
the mechanism of PBMT in the prevention of OM is investigated via the bioinformatics approach.
Methods: Six validated and significant differentially expressed genes (DEGs) associated with
the prevention of OM in head and neck cancer (HNC) patients who had experienced CRT were
extracted from the literature. After adding 50 neighbors from STRING, the network was constructed
and analyzed. The results of the action map and network analysis were compared and discussed.
Results: HLA gene family were identified as central nodes of the analyzed network. Based on action
map finding, activation is prominent action and IRF9 was the potent activator. The role of the IRF
gene family was highlighted by action map analysis.
Conclusion: Regulation of the immune system by HLA and IRF genes family is a crucial factor in the
prevention of OM in the studied patients.
Keywords :
Laser , Gene expression , IRF , HLA , Oral mucositis
